Development of an effective delivery system for intranasal immunization against Mycobacterium tuberculosis ESAT-6 antigen
نویسندگان
چکیده
منابع مشابه
Chitosan (CHT) and trimethylchitosan (TMC) nanoparticles as adjuvant/delivery system for parenteral and nasal immunization against Mycobacterium tuberculosis (MTb) ESAT-6 antigen
Objective(s): An efficient vaccine against TB is an urgent need. TB peptides are safe candidate but they are weak immunogens and needs to be potentiated by adjuvant/delivery systems. The main purpose of the present study was to determine the potential of CHT based NPs containing ESAT-6 antigen of M. tuberculosis for inducing mucosal and systemic immune responses after intranasal and subcutaneou...
متن کاملSelection of single-chain variable fragments specific for Mycobacterium tuberculosis ESAT-6 antigen using ribosome display
Objective(s): Tuberculosis (TB) is still one of the problematic infectious diseases in developing countries, especially in Iran. In the present study, we applied ribosome display technique to select single chain variable fragments (scFvs) specific for the 6-kDa early secretory antigenic target (ESAT-6) antigen of Mycobacterium tuberculosis from a mouse scFv library. Materials and Methods: The g...
متن کاملESAT-6 subunit vaccination against Mycobacterium tuberculosis.
The ESAT-6 antigen from Mycobacterium tuberculosis is a dominant target for cell-mediated immunity in the early phase of tuberculosis (TB) in TB patients as well as in various animal models. The purpose of our study was to evaluate the potential of ESAT-6 in an experimental TB vaccine. We started out using dimethyl dioctadecylammonium bromide (DDA), an adjuvant which has been demonstrated to be...
متن کاملchitosan (cht) and trimethylchitosan (tmc) nanoparticles as adjuvant/delivery system for parenteral and nasal immunization against mycobacterium tuberculosis (mtb) esat-6 antigen
objective(s): an efficient vaccine against tb is an urgent need. tb peptides are safe candidate but they are weak immunogens and needs to be potentiated by adjuvant/delivery systems. the main purpose of the present study was to determine the potential of cht based nps containing esat-6 antigen of m. tuberculosis for inducing mucosal and systemic immune responses after intranasal and subcutaneou...
متن کاملEsat-6 as an Effective Mycobacterium Tuberculosis Subunit Vaccine
Tuberculosis is still one of the important infectious diseases and a major cause for public health problems, particularly in lowand middle-income countries. Prevention of this disease is a priority of WHO. Many antigens have been candidate for vaccination. Evaluating the safety and efficacy of these antigens is the concern of many researchers. This review is about ESAT-6 as an effective Mycobac...
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ژورنال
عنوان ژورنال: Artificial Cells, Nanomedicine, and Biotechnology
سال: 2016
ISSN: 2169-1401,2169-141X
DOI: 10.3109/21691401.2016.1146735